Publications
2024
Intrinsic epigenetic state of primary osteosarcoma drives metastasis.
Singh I*, Rainusso N, Kurenbekova L, Muruganandham A*, Yustein J*
Molecular Cancer Research, 2024, 22(9): 864–878.
Genetic variation drives cancer cell adaptation to ECM stiffness.
Wang TC, Sawhney S, Morgan D, Bennett RL, Rashmi R, Estecio MR, Brock A, Singh I, Baer CF, Licht JD, Lele TP
PNAS, 2024, 121(39): e2403062121.
Atomic Vacancies of Molybdenum Disulfide Nanoparticles Stimulate Mitochondrial Biogenesis.
Singh KA, Soukar J, Zulkifli M, Kersey A, Lokhande G, Ghosh S, Murali A, Garza NM, Kaur H, Keeney JN, Sitcheran R, Singh I*, Gohil V*, Gaharwar AK*
Nature Communications, 2024, 15 (1), 8136.
Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation.
Murali A, Brokesh A, Cross L, Kersey A, Jaiswal MK, Singh I*, Gaharwar AK*
Advanced Science, 2024, 11, 29, 2402468.
Engineering a Microfluidic Platform to Cryopreserve Stem Cells: A DMSO‐Free Sustainable Approach.
16. Modaresi S, Pacelli S, Chakraborty A, Coyle A, Luo W, Singh I, Paul A
Advanced Healthcare Materials, 2024, 2401264.
Inorganic ions activate lineage-specific gene regulatory networks.
Kersey A, Singh I*, Gaharwar AK*
Acta Biomaterialia, 2024, 183, 371-386.
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.
Kersey A, Cheng YJ, Deo KA., Dubell C, Wang TC, Jaiswal M, Kim MH, Lele TP, Singh I*, Gaharwar AK
Biomaterials, 2024, 306, 122473.
2023
Inhibition of ERK 1/2 pathway downregulates YAP1/TAZ signaling in human cardiomyocytes exposed to hyperglycemic conditions.
Joddar B, Loyola CD, Ramirez SP, Muruganandham A, Singh I
Biochemical and Biophysical Research Communications, 2023.
A synthetic tumour microenvironment.
Gaharwar A, Singh I.
Nature Materials, 2023, 22: 412–413.
Omics-based approaches to guide the design of biomaterials
Kersey A, Nguyen T, Nayak B, Singh I*, Gaharwar A*.
Materials Today, 2023, 64, 98-120.
2022
Dissociation of Nanosilicates Induces Downstream Endochondral Differentiation Gene Expression Program
Brokesh A, Cross L, Kersey A, Murali A, Richter C, Gregory C, Singh I*, Gaharwar AK*
Science Advances, 2022, 8, 17, abl9404
LB892 Distinct endothelial behaviors orchestrate developing versus adult skin vascular responses
C Kam, Singh I, P Sola, G Solanas, J Bonjoch, C Matte-Martone, D Gonzalez, E Marsh, K Hirschi, V Greco
Journal of Investigative Dermatology, 2022
2021
ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Arabzade A, Zhao Y, Varadharajan S, Chen H-S, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, Leon LAD, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC*
Cancer Discovery , 2021
2020
Engineered Biomaterials for In situ Tissue Regeneration
Gaharwar AK, Singh I, Khademhosseini A
Nature Review Materials, 2020 5, 686–705
Photothermal Modulation of Human Stem Cells Using Light-responsive 2D Nanomaterials
Carrow J., Singh KA, Jaiswal MK, Ramirez A, Lokhande A, Yeh A, Sarkar TA, Singh I*, Gaharwar AK*
Proceedings of the National Academy of Sciences, 2020, 117 (24) 13329-13338
Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue
Chimene D, Miller L, Cross L, Jaiswal MK, Singh I, Gaharwar AK
ACS Applied Materials & Interfaces, 2020, 12 (14), 15976-15988
2019
A C19MC-MYCN-LIN28A oncogenic circuit driven by hijacked super-enhancers represents a distinct therapeutic vulnerability in ETMRs
Sin-Chan P*, Mumal I*, Suwal T, Ho B, Xiaolian F, Singh I, Lu M, Torchia J, Lovejoy DB, Guilhamon P, Fouladi M, Lassaletta A, Afzal S, Philips J, Solano-Paez P, Lindsey M. Hoffman, Van Meter T, Leary S, Nakamura H, Massimi L, Grundry R, Fangusaro J, Johnston D, Hwang E, Wang Y, Scharnhorst D, Camelo-Piragua S, Reddy A, Gillespie Y, Catchpoole D, Hansford J, Gil da Costa MJ, Michaud J, Levy JM, Ellezam B, Ramanujachar R, Lindsay HB, Singh SK, Jabado N, Kleinman CL, Taylor MD, Hawkins CE, Bouffet E, Arrowsmith CH, Dirks PB, Li XN, Lin CY, Rich JN, Mack SC, Huang A
Cancer Cell , 2019, 36 (1), 51-67. e7
Chromatin landscapes reveal developmentally encoded transcriptional states that define glioblastoma
Mack SC*,Singh I, Wang X, Hirsch R, Wu Q, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Villagomez R, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN
Journal of Experimental Medicine, 2019, 216 (5), 1071
2018
Non-overlapping control of transcriptome by Promoter and Super-Enhancer-Associated Dependencies
Fulciniti M, Lin CY, Samur MK, Lopez MA, Singh I, Lawlor MA, Szalat RE, Ott CJ, Avet-Loiseau H, Anderson KC, Young RA, Bradner JE, Munshi NC
Cell Reports, 2018, 25: 3693-3705.e6
Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia
Lee S, Singh I, Lee S, Tisdale S, Abdel-Wahab O, Leslie C, Mayr C
Nature, 2018, 561, 127–131
Widespread intronic polyadenylation diversifies immune cell transcriptomes
Singh I, Lee S, Sperling A, Samur MK, Tai Y, Fulciniti M, Munshi N, Mayr C, Leslie C
Nature Communications, 2018, 9: 1716
Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates
Carrow J, Cross L, Reese R, Jaiswal M, Gregory C, Kaunas R, Singh I*, Gaharwar A
Proceedings of the National Academy of Sciences, 2018, 115, E3905-E3913
2015
An allelic series of miR-17~92 mutant mice uncovers functional specialization and cooperation among members of a miRNA polycistron
Han Y, Vidigal J, Mu P, Yao E, Singh I, Gonzalez A, Concepcion C, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A
Nature Genetics, 2015, 47, 766–775
2013
Global profiling of stimulus-induced polyadenylation in cells using a poly (A) trap
Curanovic D, Cohen M, Singh I, Slagle CE, Leslie CS, Jaffrey SR
Nature Chemical Biology, 2013, 9, 671–673
2011
Virus interactions with human signal transduction pathways
Zhao Z, Xia J, Tastan O, Singh I, Kshirsagar M, Carbonell J and Klein-Seetharaman J
International Journal of Computational Biology and Drug Design, 2011, 4(1): 83–105
Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provides insights into adoption of a parasitic lifestyle and prospects for disease control
Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Badger JH, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG
Genome Biology, 2011, 12(10): R100
2010
Comparison of virus interactions with human signal transduction pathways
Singh I, Tastan O and Klein-Seetharaman J
Proceedings of the First Association of Computing Machinery (ACM), 2010, 17-24